Link, Google Scholar; 27 Flaherty KR, Thwaite EL, Kazerooni EA, et al. Case Discussion. Take a quiz on differentiating between chronic hypersensitivity pneumonitis (HP), nonspecific interstitial pneumonia (NSIP), and usual interstitial pneumonia (UIP). In NSIP, fine reticular opacities and microcystic honeycombing represent fibosis while ground glass opacities without traction bronchiectatic changes possibly represent inflammation. There is a well known association of NSIP with SLE.. Pathological classification. NSIP 36. Thorax 2003; 58: 143–148. Three pathologists (TVC, WDT, AF) blinded to the clinical and radiological features reviewed the biopsy specimens. LIP lymphoid interstitial pneumonia, NSIP nonspecific interstitial pneumonia, RB-ILD respiratory bronchiolitis–associated interstitial lung disease, UIP usual interstitial pneumonia RadioGraphics 2007; 27:595–615 Published online 10.1148/rg.273065130 Content Code: Radiology 2007; 245: 267–275. In a study by McDonald and coworkers of 21 patients with NSIP and 32 patients with UIP, the sensitivity, specificity, and accuracy of a CT diagnosis of NSIP were 70, 63, and 66%, respectively . Clinical; Insidious onset of dyspnea, cough, fatigue; Mean age 40-50, may be seen in children; Pulmonary function tests: restrictive with decreased diffusing capacity; Generally less severe than UIP; Overall 80=90% 5 year survival Responds to steroids; High resolution computed tomography (HRCT) It can be normal in early stage of disease and in plain radiographs. NSIP may be idiopathic or associated with collagen vascular diseases or exposure to drugs or chemicals. A usual interstitial pneumonia (UIP) pattern on chest CT scans is highly suggestive of UIP pathologic findings; the most common cause of UIP is idiopathic pulmonary fibrosis (IPF) [1–5].Under current guidelines, a UIP pattern on CT images is specific for IPF after a thorough clinical and serologic workup has excluded other causes of interstitial lung disease (ILD) []. NSIP; Diagnostic Criteria. Radiological versus histological diagnosis in UIP and NSIP: survival implications. The study included 54 patients with NSIP and … Each specimen was assigned a histological diagnosis of UIP or NSIP using defined criteria. 10 Several studies have evaluated the ability to differentiate between UIP and NSIP by HRCT. Idiopathic pulmonary fibrosis (IPF), the most common and lethal of the idiopathic interstitial pneumonias, is defined by a radiological and/or pathological pattern of usual interstitial pneumonia (UIP). 35 Organizing pneumonia is characterized by the presence of consolidation and may also show features of fibrosis reminiscent of NSIP. This outcome is quite different from that seen in UIP, which has a poor prognosis. Materials and Methods: Institutional review board approval was obtained for this retrospective study; informed consent was not required. UIP/IPF – gross specimen Small, firm, fibrosed lung seen in advanced disease 32. UIP/IPF – gross specimen White tissue represents interstitial fibrosis 33. Purpose: To determine whether concurrent emphysema influences the distinction between usual interstitial pneumonia (UIP) and nonspecific interstitial pneumonia (NSIP) at thin-section computed tomography (CT). Organizing pneumonia is caused by inflammation 10 and may be idiopathic in nature, termed cryptogenic organizing pneumonia, or may occur secondary to infection, collagen vascular disease, or drug toxicity. Cryptogenic Organizing Pneumonia. NSIP has a relative good prognosis and the majority of patients respond to treatment with corticosteroids. Differentiating Chronic HP, NSIP, & UIP – Radiology Rounds Crossref, Medline, Google Scholar; 28 Kim EY, Lee KS, Chung MP, Kwon OJ, Kim TS, Hwang JH. {Extrapulmonary manifestations 35. 3, 19 A patient received a diagnosis of UIP when one or more biopsy specimens showed UIP. UIP/IPF – histologic section Spatial heterogeneity: fibrosis with interspersed normal lung 34.

uip vs nsip radiology

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